Continuous crystallization
Secondary Nucleation for the Intensification of Continuous Crystallization (SNICC)
Many products in the chemical, food and pharmaceutical industry are produced as powders through a crystallization process. Continuous crystallization has become more recently a key component of the new paradigm, i.e. the continuous manufacturing of active pharmaceutical ingredients. All product crystals of continuous crystallization processes are formed through secondary nucleation, which is both ubiquitous and elusive.
The project SNICC intends to unveil the microscale mechanisms of secondary nucleation, and to bring its scientific understanding to a level where it can be exploited to model, design, operate, optimize and control continuous crystallization processes at any desired scale.
The SNICC project has been awarded an Advanced Grant by the European Research Council.
References
- external page LT Deck and M Mazzotti: General stability analysis of the steady states in the continuous mixed-suspension crystallizer, Chem. Eng. J. (2024), 483, 148721.
- external page LT Deck and M Mazzotti: Conceptual Validation of Stochastic and Deterministic Methods To Estimate Crystal Nucleation Rates, Cryst. Growth Des. (2023), 23, 2, 899-914.
- external page B Ahn, M Chen and M Mazzotti: Online Monitoring of the Concentrations of Amorphous and Crystalline Mesoscopic Species Present in Solution, Cryst. Growth Des. (2022), 22, 8, 5071-5080.
- external page R Achermann, V Wiedmeyer, MS Hosseinalipour, S Güngör and M Mazzotti: Model-based design of pressure-driven product removal from stirred suspensions, Chem. Eng. Res. Des. (2021), 174, 57-70.
- external page L Bosetti and M Mazzotti: Population Balance Modeling of Growth and Secondary Nucleation by Attrition and Ripening, Cryst. Growth Des. (2020), 20, 1, 307-319.